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Glucose Metabolism in the Heart. The heart is an omnivore, consuming fuel constantly and using any substrate available. 8 The high rates of ATP production and turnover are critical in maintaining cardiac contractility to deliver blood and oxygen to the other organs. Under normal conditions, cardiac ATP is mainly derived from fatty acid (FA) oxidation (FAO), with glucose metabolism contributing
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In a single ascending dose (SAD) study (0.5 mg to 600 mg) and multiple ascending dose (MAD) study for 14 days (250 mg of BID to 500 mg of QD) in healthy volunteers, GDC0853 was very well tolerated with no severe adverse events, no safety signals, and no dose limiting toxicities.
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